All-Star Superman #9. Superman returns to Earth only to find a couple of Kryptonian astronauts have taken up his role only as in true Kryptonian style they decide to become petty tyrants. From their behaviour to their wonderfully alien costumes (head antennas included) they just do not seem anything like Superman. They bring a sense of hyperactive aristocracy to Earth and since they can they decide to take over and creaete New Krypton - something that happens a heck of a lot when Kryptonians other than Superman show up.
Well this Superman just doesn't stop trying to help these two even when they break the moon then stitch it up with the world's famous bridges. It's his ability to be both alien and human that rises him above the other characters here - from Clark Kent's antagonist Steve Lombard to Superman's antagonists Bar-El and Lilo. He's got the power of the aliens, which is their strength but the compassion of humans, which is their strength.
The bright colours make this feel like mainlining comic books into your system. The art is simultaneously awe inspiring, wonderfully kinetic and horribly alien and threatening. And the ending is both happy and forboding with the mini-tyrants in the Phantom Zone looking happy to take over a bunch of Kryptonian criminals but their look could be one of patience to eventually come back to trouble Superman or one of simple satisfaction because they get to do what they like (beat people into submission).